Senin, 30 Desember 2019

He Jiankui: Chinese gene-editing scientist jailed for 3 years - CNN

He Jiankui shocked the world in 2018 when he announced that twin girls Lulu and Nana had been born with modified DNA to make them resistant to HIV, which he had managed using the gene-editing tool CRISPR-Cas9 before birth.
He, an associate professor at the Southern University of Science and Technology in Shenzhen, said at the time that he was "proud" of the achievement. He later claimed that a second woman was pregnant as a result of his research.
But he was condemned by many of his peers, with the experiment labeled "monstrous," "unethical," and a "huge blow" to the reputation of Chinese biomedical research. Many people within the scientific community raised ethical concerns, including the level of consent He had obtained from the parents of the babies, and the level of transparency around gene editing.
On Monday, the Shenzhen Nanshan District People's Court sentenced He to three years behind bars and a 3 million yuan ($430,000) fine, China's state-run news agency Xinhua reported.
China suspends scientists who claim to have produced first gene-edited babies
According to the court's findings, He became aware of potential economic gains from human embryo gene-editing technology in 2016, Xinhua reported. He worked with two medical researchers, Zhang Renli and Qin Jinzhou, to use gene-editing technology to produce babies that were resistant to HIV.
"The court held that the three defendants failed to obtain a doctor's qualification and pursued profit, deliberately violated the relevant national regulations on scientific research and medical management, crossed the bottom line of scientific and medical ethics, and rashly applied gene-editing technology to human-assisted reproductive medicine, and disrupted the medical treatment," Xinhua reported. "The nature of their behavior is serious and has constituted the crime of illegal medical practice."
Zhang was sentenced to two years in prison and fined 1 million yuan ($143,000), while Qin was given a suspended sentence of one year and six months in prison and fined 500,000 yuan ($71,600). According to Xinhua, all three defendants pleaded guilty in trials that were closed to the public to protect individual privacy.
All three defendants have reportedly also been banned from engaging in human-assisted reproductive technology services for life.
Editing the genes of embryos intended for pregnancy is banned in many countries, including the United States. In the United Kingdom, embryos can only be edited for research purposes with strict regulatory approval. It is unknown whether the procedure is safe or, if used in pregnancy, whether it can have unintended consequences for the babies later in life or for future generations.
In January this year, investigators from Guangdong Province Health Commission said that He had conducted the work "in pursuit of personal fame and fortune, with self-raised funds and deliberate evasion of supervision and private recruitment of related personnel." The authorities also said He forged ethical review documents and blood tests to circumvent a ban on assisted reproduction for HIV-positive patients.
China has invested heavily in gene-editing technology, with the government bankrolling research into a number of world "firsts," including the first use of the gene-editing tool CRISPR-Cas9 in humans in 2016 and the first reported use of gene editing technology to modify nonviable human embryos in 2015.

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2019-12-30 07:41:00Z
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Chinese Scientist Who Genetically Edited Babies Gets 3 Years in Prison - The New York Times

BEIJING — A court in China on Monday sentenced He Jiankui, the researcher who shocked the global scientific community when he claimed that he had created the world’s first genetically edited babies, to three years in prison for carrying out “illegal medical practices.”

In a surprise announcement from a trial that was closed to the public, the court in the southern city of Shenzhen found Dr. He guilty of forging approval documents from ethics review boards to recruit couples in which the man had H.I.V. and the woman did not, the state broadcaster China Central Television reported. Dr. He had said he was trying to prevent H.I.V. infections in newborns, but the state media on Monday said he deceived the subjects and the medical authorities alike.

Dr. He sent the scientific world into an uproar last year when he announced at a conference in Hong Kong that he had created the world’s first genetically edited babies — twin girls. On Monday, China’s state media said his work had resulted in a third genetically edited baby, who had been previously undisclosed.

Dr. He pleaded guilty and was also fined $430,000, according to Xinhua, China’s official news agency. In a brief trial, the court also handed down prison sentences to two other scientists who it said had “conspired” with him: Zhang Renli, who was sentenced to two years in prison, and Qin Jinzhou, who got one and a half years.

Dr. He’s declaration made him a pariah among scientists and drew scrutiny to China’s scientific ambitions. Though Dr. He offered no proof and did not share any evidence or data that definitively proved he had done it, his colleagues had said it was possible that he had succeeded.

During the Hong Kong conference, Dr. He said he used in vitro fertilization to create human embryos that were resistant to H.I.V., the virus that causes AIDS. He said he did it by using the Crispr-Cas9 editing technique to deliberately disable a gene, known as CCR₅, that is used to make a protein H.I.V. needs to enter cells.

The international condemnation from the scientific community that followed Dr. He’s announcement came because many nations, including the United States, had banned such work, fearing it could be misused to create “designer babies” and alter everything from eye color to I.Q.

Although it is not against the law to do so in China, the practice is opposed by many researchers there. China’s vice minister of science and technology said last year that Dr. He’s scientific activities would be suspended, calling his conduct “shocking and unacceptable.” A group of 122 Chinese scientists called Dr. He’s actions “crazy” and his claims “a huge blow to the global reputation and development of Chinese science.”

The court said the trial had to be closed to the public to guard the privacy of the people involved.

Dr. He’s whereabouts had been something of a mystery for the past year. After his announcement, he was placed under guard in a small university guesthouse in Shenzhen and he has made no statements since. But his conviction was a foregone conclusion after the government said its initial investigation had found that Dr. He had “seriously violated” state regulations.

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2019-12-30 06:46:00Z
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Minggu, 29 Desember 2019

Ukraine, Russia-backed rebels swap prisoners in latest sign of peace efforts - NBC News

The Ukrainian government and Russian-backed separatist forces held a prisoner swap in the country's war-ravaged east Sunday in the latest sign of efforts to ease tensions between the two warring sides.

The exchange was agreed upon by President Volodymyr Zelenskiy and Russian President Vladimir Putin during peace talks in Paris earlier this month.

The negotiations did not result in a peace deal to end the deadly five-year military conflict, but the two parties committed to further talks and a prisoner exchange before the year is out.

Ukraine said 76 of its prisoners were returned, while media reports suggested Kyiv released 123 prisoners to the rebels.

SBU, Ukraine’s security service, said after the swap that 12 of those returned were servicemen, while the other 64 were civilians.

"This exchange is proof of how important it is for Ukraine's president to protect every Ukrainian who is in difficult circumstances because of Russian aggression," said SBU chief Ivan Bakanov in a statement.

Armed troops from both sides looked on as buses arrived at the swap site Sunday morning, a checkpoint near the industrial town of Horlivka in the Donetsk region.

Photos shared in Ukrainian media showed prisoners being loaded on and off buses, with some being greeted by their loved ones.

Others were handed hot drinks and slices of cake to celebrate their release.

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Released prisoners eat cake after they were exchanged in a swap at the Mayorsk crossing point in eastern Ukraine on Sunday. Ukrainian Presidential Press Service / via Reuters

The last major prisoner exchange between separatist rebels and Ukrainian forces took place in December 2017, with 233 rebels exchanged for 73 Ukrainians.

Sunday’s swap comes several months after a direct prisoner exchange between Ukraine and Russia in September. That saw 24 Ukrainian sailors detained by Russia in a naval confrontation in late 2018 freed, among others.

The swap was considered a major victory for Zelenskiy, who made the return of the sailors one of his election promises.

The Ukrainian leader, who was a comedian without any political experience before he took office earlier this year, was thrust into the international spotlight following a phone conversation with President Donald Trump in July.

The call has become the focal point of an impeachment inquiry in the U.S. that will see Trump face a Senate trial after being impeached by the House earlier this month.

Dec. 28, 201901:52

The saga has dominated Washington politics, and been a distraction for Zelenskiy as he juggles peace negotiations with efforts to revive the country’s struggling economy and tackle rampant corruption.

Eastern Ukraine has been ravaged by years of war between government forces and separatists backed by Russia, sparked in the aftermath of the 2014 mass protests in Kyiv.

The talks in Paris earlier this month renewed hopes for a resolution to the conflict, which has claimed more than 13,000 lives.

The United States has backed Ukraine throughout the conflict, fearing Putin’s efforts to extend Moscow’s geopolitical influence.

It has also heavily sanctioned Russia for its military intervention and the annexation of Crimea.

The U.S. Embassy in Kyiv welcomed the prisoner swap.

"Recognizing that Russia's ongoing aggression confronts Ukraine's leadership with difficult choices, we stand in solidarity with our Ukrainian partners and the many Ukrainians who remain in captivity in Russia and Crimean," the embassy said in a statement.

Trump's decision to put a temporary hold on U.S. military aid, a central issue in the impeachment process, has raised concerns it could undermine Ukraine's efforts to contain Russian aggression.

Zelenskiy campaigned on ending the conflict, which is ongoing despite a ceasefire signed in 2015. He has taken a number of steps toward peace since coming into power, culminating in his face-to-face talks with Putin in Paris.

He has faced some opposition at home for what some have dubbed a “capitulation” to Russia. However, a recent poll showed 75 percent of Ukrainians support his talks with Putin to resolve the conflict.

Reuters and Associated Press contributed.

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2019-12-29 15:40:00Z
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Ukraine, Russia-backed rebels swap prisoners in latest sign of peace efforts - NBC News

A prisoner swap between the Ukrainian government and Russian-backed separatist forces in the country's east was underway Sunday in the latest sign of efforts to ease tensions between the two warring sides.

The exchange was agreed upon by President Volodymyr Zelenskiy and Russian President Vladimir Putin during peace talks in Paris earlier this month.

The negotiations did not result in a peace deal to end the deadly five-year military conflict, but the two parties committed to further talks and a prisoner exchange before the year is out.

The swap was expected see Ukraine hand over 87 separatists in exchange for 55 pro-government Ukrainians.

Armed troops from both sides looked on as buses arrived at the swap site, a checkpoint near the industrial town of Horlivka in the Donetsk region.

Ukrainian war prisoners escorted by Russia-backed separatist soldiers walk to be exchanged near the checkpoint Horlivka, eastern Ukraine, on Sunday.Alexei Alexandrov / AP

The last major prisoner exchange between separatist rebels and Ukrainian forces took place in December 2017, with 233 rebels exchanged for 73 Ukrainians.

Let our news meet your inbox. The news and stories that matters, delivered weekday mornings.

Sunday’s swap comes several months after a direct prisoner exchange between Ukraine and Russia in September. That saw 24 Ukrainian sailors detained by Russia in a naval confrontation in late 2018 freed, among others.

The swap was considered a major victory for Zelenskiy, who made the return of the sailors one of his election promises.

The Ukrainian leader, who was a comedian without any political experience before he took office earlier this year, was thrust into the international spotlight following a phone conversation with President Donald Trump in July.

The call has become the focal point of an impeachment inquiry in the U.S. that will see Trump face a Senate trial after being impeached by the House earlier this month.

Dec. 28, 201901:52

The saga has dominated Washington politics, and been a distraction for Zelenskiy as he juggles peace negotiations with efforts to revive the country’s struggling economy and tackle rampant corruption.

Eastern Ukraine has been ravaged by years of war between government forces and separatists backed by Russia, sparked in the aftermath of the 2014 mass protests in Kyiv.

The talks in Paris earlier this month renewed hopes for a resolution to the conflict, which has claimed more than 13,000 lives.

The United States has backed Ukraine throughout the conflict, fearing Putin’s efforts to extend Moscow’s geopolitical influence.

It has also heavily sanctioned Russia for its military intervention and the annexation of Crimea.

Trump's decision to put a temporary hold on U.S. military aid, a central issue in the impeachment process, has raised concerns it could undermine Ukraine's efforts to contain Russian aggression.

Zelenskiy campaigned on ending the conflict, which is ongoing despite a ceasefire signed in 2015. He has taken a number of steps toward peace since coming into power, culminating in his face-to-face talks with Putin in Paris.

He has faced some opposition at home for what some have dubbed a “capitulation” to Russia. However, a recent poll showed 75 percent of Ukrainians support his talks with Putin to resolve the conflict.

Reuters and Associated Press contributed.

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2019-12-29 12:46:00Z
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10 ways North Korea uses technology to keep its citizens in the dark about the outside world - Business Insider

  • North Korea is nicknamed the hermit kingdom – a hermetically sealed dictatorship where it’s hard for both people and information to get in or out.
  • But the advent of the internet and accompanying technologies means it is easier than ever for North Koreans to access foreign media, films, radio, and even pornography.
  • A new report from the Committee for Human Rights in North Korea details the way in which North Korea’s supreme leader Kim Jong-un also uses technology to counter this influx of information.
  • The measures range from death sentences and imprisonment for watching banned media, to sealing off the country’s domestic mobile network from foreign tourists visiting the country.
  • Visit Business Insider’s homepage for more stories.

How do you keep a country hermetically sealed off from the news in a world where the internet exists?

That’s the fundamental challenge for North Korea, the hermit kingdom whose citizens have been kept in the dark both literally and figuratively. The internet, smartphones, laptops, TV, film, radio exist, but not as most people would be familiar with them. Radio and TV sets are configured so North Koreans can’t tune into anything other than the domestic broadcasts, and the internet isn’t widely accessible to the population.

But it’s increasingly hard for North Korea’s supreme leader, Kim Jong-un, to control the stream of illicit microSD cards and SIM cards flowing over the border from China, which contain illegal foreign media or allow people to access the internet unfettered.

A new report by journalist and North Korea tech expert Martyn Williams for the Committee for Human Rights in North Korea (HRNK) sheds new light on the ways Kim and his regime use technology to continue keeping the population in the dark – from signal jamming radios to modifying Android to spy on people.


1. North Korea tightly controls the internet

Foto: In this June 16, 2017, photo, North Korean students use computer terminals at the Sci-Tech Complex in Pyongyang, North Korea.sourceAP

North Korea isn’t totally cut off from the internet, as evidenced by the numerous hacks thought to be perpetrated by state hackers operating inside the country.

But it is tightly controlled at the network level and historically hasn’t really been open to the general population. That is changing, with more citizens buying smartphones.

As Martyn Williams notes in his report: „The entire infrastructure is State-run and the security services are heavily integrated in the running of the telecommunications network.“

Everything is monitored by a state agency called Bureau 27, or the Transmission Surveillance Bureau.


2. North Korea imports cheap Chinese Android phones, then modifies the software to spy on people

Foto: A North Korean woman talks on her mobile phone as she skates on an ice rink in Pyongyang, North Korea Tuesday, Dec. 18, 2018.sourceAP

North Korea isn’t totally cut off from everyday innovations like mobile data or smartphones. Citizens can buy smartphones that were manufactured in China, but are distributed under a North Korean brand name. The phones look a lot like the cheap Android phones you could buy in any shop – but these come pre-loaded with spyware and software tailored by the state.

Alternatively, citizens can buy their own unlocked devices smuggled across the Chinese border, but they face being tracked via North Korea’s mobile network.

It’s the same on PCs, with North Korea producing a Linux-based operating system called „Red Star“ that can snoop on user activity.


3. The spyware can monitor what sites people are looking at

Foto: In this Friday, June 16, 2017, photo, the homepage of the Sci-Tech complex is seen on a computer screen in Pyongyang, North KoreasourceAP

According to Williams, North Korean phones run on Android, the open source mobile software. Engineers have modified the software to include a background program called „Red Flag“, which spies on everything a user does and takes screenshots at random intervals to capture their activity. Those screenshots are recorded on a database called „Trace Viewer.“

Although North Korea probably doesn’t have the resources to check everyone’s screenshots, Williams noted that it’s a great mechanism to get people to self-censor out of pure fear.


4. If you open a foreign media file on a North Korean device, the regime will know about it

Foto: In this May 5, 2015 file photo, a man sits in front of portraits of the late North Korean leaders Kim Il Sung, left, and Kim Jong Il, right, as he uses his smartphone in Pyongyang, North Korea.sourceAP

According to the report, North Korean engineers created file watermarking software that essentially tags and monitors any media file that’s opened on a device, whether that’s a PC or mobile.

Anyone watching a foreign film on their device would have that file tagged and tracked. The tag can track every device on which the file is viewed – so if one person in particular is distributing lots of foreign media with fellow citizens, the regime would probably find out.


5. The state operates a ’split‘ mobile network, where North Koreans can’t phone anyone outside the country

Foto: North Korean woman holding a Huawei mobile phone, Pyongan Province, Pyongyang, North Korea on April 26, 2010 in Pyongyang, North Korea.sourcePhoto by Eric Lafforgue/Art In All Of Us/Corbis via Getty Images

North Korea does have a telecommunications system, and the current version is a joint venture with an Egyptian firm called Orascom.

The network is split into two halves, according to Williams‘ report, meaning both North Korean tourists and foreign citizens can make calls and send texts inside the country – but neither can communicate with the other.

Described as a „firewall“, Williams writes that this is set at the account level. He adds that domestic citizens have phone numbers prefixed with 191-260, while phones for foreigners have numbers that begin with 191-250.

Tourist SIM cards have found their way back into the country – so North Korea has begun deactivating them so there’s no risk citizens can get hold of SIM cards that let them access the broader internet or foreign calls.


6. It’s probably a death sentence for watching porn

Foto: sourceAlain Pitton/NurPhoto via Getty Images

Williams spoke to a number of North Korean defectors, people who fled the regime into China, Japan, or South Korea.

They reported that the regime will put people to death for watching foreign content, especially for anything as illicit as porn, or anything criticizing the Kim family.

„Watching pornography is strongly restricted. I’ve heard you can get executed for watching pornography,“ according to one escapee.

An Amnesty International report also found that a man who watched porn with his wife and another woman was executed, with the entire city summoned to watch his death.


But porn smuggled in on discs remains highly valuable, costing as much as $500

Foto: sourceFlickr / Privatenobby

Unsurprisingly, few escapees are willing to talk about their porn habits.

But citing a source who knows about illegal smuggling between North Korea and China, Williams states that SD cards containing porn can fetch up to $500. That price reflects both the high demand and the extreme risk of smuggling the material across.


7. All radios sold in North Korea are fixed to government frequencies

Foto: In this Aug. 25, 2016 photo, North Korean defector Park Kyung-hwa who works for a Seoul-based shortwave radio station targeting audience in North Korea, demonstrates how she records her broadcast at a church in Seoul, South Korea.sourceAP Photo/Jungho Choi

North Koreans buying a radio through official channels will find the device locked only onto government-approved frequencies. Listening to foreign radio, or watching foreign TV, is illegal and the government regularly carries out raids to make sure people aren’t consuming anything subversive. (Lots of North Koreans have a second radio or TV which can receive foreign broadcasts and which they keep hidden, and show their „official“ device to any inspectors.)

According to Williams, North Korea jams foreign radio signals. This, he writes, involves „transmitting loud noise“ on the same frequencies to overpower the broadcast. In particular, North Korea focuses on jamming two stations run by South Korea’s intelligence service, called Voice of the People and Echo of Hope.


8. The state distracts people with homegrown mobile games

Foto: North Korea’s ‚King of Scoring 2019‘ mobile gamesourceArirang Meari

In a cloistered world where entertainment is low-quality or scarce, food is hard to come by, and the work repetitive and unfulfilling, it’s little wonder that foreign films and international TV holds some allure to North Korean citizens.

The state has, according to Williams‘ report, come up with a softball distraction method: offer homegrown smartphone games.

The report claims there are up to 125 mobile games available to play on North Korean mobile devices, such as „Volleyball 2016“ and another title called „Future Cities.“ The BBC in September reported that North Korea had created a Ronaldo-focused mobile game that was becoming popular.

The idea is this: if citizens spend their leisure time playing domestically produced games (and paying for them), they’re not spending their cash on illegally smuggled media.


9. Open WiFi networks are banned

Foto: This Dec. 23, 2017, photo, shows a sign for the new WiFi service being offered in the departures lobby of Pyongyang’s international airport. Despite being one of the least Internet-friendly countries in the world, North Korea’s main Internet provider recently set up an airport WiFi network that is available to travelers who have cleared customs. Access to WiFi and the Internet in general remains beyond the reach of most North Koreans.sourceAP photo/Eric Talmadge

North Korea has gone to extreme lengths to make sure its citizens can’t casually access the foreign internet (or any internet).

For a time, according to Williams‘ report, foreign embassies in capital city Pyongyang ran open WiFi networks. Enterprising citizens with smartphones lingered nearby to browse the internet without being caught – until the state cottoned on and banned open networks.

Eventually, North Korea introduced its own public Mirae (Korean for „future“) public network. It requires an app to use and, according to state media, only offers people access to North Korea’s intranet and not the global internet.


10. Shifting to tightly controlled streaming TV tech

Foto: Televisions made by a North Korean company are displayed at an international exhibition in Pyongyang on Sept. 23, 2019.sourceKyodo News via Getty Images

North Korea doesn’t have Netflix but, like much of the rest of the world, it is shifting to streaming TV.

According to Williams‘ report, there are two homegrown IPTV services, but the more popular one is called Manbang. Just like phones, the set-top box is built cheaply in China, imported, then reskinned as a domestically branded device.

People who own a Manbang device can stream a huge amount of state output, but can’t tune into to foreign services. For now, people can also tune into traditional, over-the-air broadcasts (including foreign ones, if they have a hidden TV set). But, Williams concludes, North Korea could ban traditional broadcasts altogether and only put out content through IPTV.

This would make it even tougher for North Koreans to access foreign broadcasts.

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2019-12-29 09:02:49Z
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Russia and Ukraine in controversial prisoner swap - BBC News

Russia and Ukraine have begun the final phase of a long-awaited prisoner exchange, the office of the Ukrainian president said on Sunday.

Authorities agreed to the swap - aimed at improving relations between the two countries - at talks in December.

Ukraine is expected to hand over 87 separatists, while Russia will return 55 pro-Ukrainian fighters.

Relations between the two countries deteriorated in 2014, when Russia annexed Ukraine's Crimean peninsula.

Russian-backed rebels then began an insurgency in the Donetsk and Luhansk regions of eastern Ukraine. More than 13,000 people have been killed in the conflict.

This is the second prisoner exchange between the nations. In September, 24 sailors seized by Russia in the Kerch Strait off Crimea in November 2018 were released and - controversially - a "person of interest" over the downing of flight MH17 which killed 298 people was handed to Russia.

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Sunday's swap is taking place at a check point near the industrial town of Horlivka in the Donetsk region.

"At the Mayorske checkpoint the process of releasing detained persons has begun," the official Twitter account of the Ukrainian president said on Sunday.

Ukrainian activists opposed to the swap blockaded the exit to the prison in the capital where some of the pro-Russian prisoners were being held.

They objected to the release of former members of the Berkut - the Ukrainian riot police accused of killing forty-eight people during pro-democracy demonstrations in February 2014.

In a statement on Saturday, Ukraine's prosecutor-general's office said that defendants facing trial would still have to appear in court.

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2019-12-29 10:58:06Z
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Sabtu, 28 Desember 2019

Hong Kong police arrest protesters in shopping mall - Reuters Australia

HONG KONG (Reuters) - Hong Kong police arrested about a dozen protesters and used pepper spray on Saturday to break up a protest in a shopping mall aimed at disrupting retail businesses near the border with mainland China.

Demonstrators have been targeting malls across Hong Kong since earlier this week and more than a hundred protesters, many dressed in black with face masks, marched through a mall in Sheung Shui on Saturday, chanting “Go back to China”.

Sheung Shui, which is just over the border from the Chinese city of Shenzhen, is popular with so-called parallel traders who buy large volumes of duty-free goods in Hong Kong and then sell them on the mainland.

The Chinese traders have become a target for protesters in Hong Kong, who are blame them for overcrowding and pushing up prices and rents.

“Our intention is to make shops close their gates. There are many parallel traders, we want to cast them out,” said Kelly, a 17-year-old protester wearing mask.

Police wrestled one protester to the ground and pepper sprayed his face before handcuffing him. Many shops closed early and shoppers hurried out of the mall. 

The protests in Hong Kong began more than six months ago in response to a now-withdrawn bill that would have allowed extraditions to mainland China, where courts are controlled by the Communist Party.

The demonstrations have since evolved into a broader pro-democracy movement and became more confrontational over the festive season.

More protests are planned in the next few days, including a countdown to New Year’s Day and a march on Jan. 1 organized by the civil human rights front that could attract thousands.  

Many protesters have been angered by what they see as the use of unnecessary force by police and have demanded an independent inquiry into the force’s behavior.

Slideshow (11 Images)

Hong Kong police have earned a total of $17.3 million in meal and work-related allowances during the past six months of anti-government protests, government figures showed on Friday.

Demonstrators are also angry at what they perceive as increased meddling by Beijing in freedoms promised to the former British colony when it returned to Chinese rule in 1997. 

China denies interfering, saying it is committed to the “one country, two systems” formula put in place at that time, and blames foreign forces for fomenting unrest. 

Writing by Clare Jim; Editing by David Clarke

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2019-12-28 15:51:57Z
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